Emideltide (DSIP)
In a six-person double-blind crossover, DSIP raised median total sleep by 59% during 130 minutes versus placebo (PMID 6895513; checked 24 Aug 2026). PubMed lists no grant. The full-paper funder was not checked. The authors reported no mental, body, or lab side effects (PMID 6895513; checked 24 Aug 2026). A later 16-person study found weak measured effects and no likely major benefit (PMID 1299794; checked 24 Aug 2026).
What substance and sequence does DSIP identify?
The American FDA/NCATS GSRS displays Emideltide as the INN (GSRS; checked 24 Aug 2026). It lists DSIP and delta sleep-inducing peptide as names. Its nine-part sequence is WAGGDASGE.
GSRS assigns UNII YN28Z5YZ73 (checked 24 Aug 2026). It assigns primary CAS 62568-57-4 (same source and date). It also lists CAS 69431-45-4 as NO STRUCTURE GIVEN. The old PubMed records use that second number.
What did the first controlled human sleep study find?
| Design | Measured finding | Primary source | Funder status | Checked |
|---|---|---|---|---|
| 6 healthy volunteers; double-blind crossover | Median total sleep rose 59% in 130 minutes versus placebo | PMID 6895513 | PubMed has no grant list; full paper not verified | 24 Aug 2026 |
| Same study; later night sleep | Shorter sleep onset, less stage 1 sleep, better sleep efficiency | PMID 6895513 | Same status | 24 Aug 2026 |
| Same study; observed safety | Well tolerated; no psychological, physiological, or biochemical side effects reported | PMID 6895513 | Same status | 24 Aug 2026 |
The study found no classic drug sedation.
What did later human studies measure?
| Study | Result | Primary source | Funder status | Checked |
|---|---|---|---|---|
| 16 chronic insomnia patients; double-blind matched pairs | Higher sleep efficiency and shorter latency versus placebo; effects weak and partly possibly due to placebo change | PMID 1299794 | PubMed has no grant list; full paper not verified | 24 Aug 2026 |
| Same 16-patient study | No change in other measures, including subjective sleep quality; authors concluded no likely major benefit | PMID 1299794 | Same status | 24 Aug 2026 |
| 11 healthy men; randomized double-blind crossover | ACTH-like immunoreactivity fell for at least 3 hours; plasma cortisol was unchanged | PMID 2554357 | PubMed says non-US government support; agency not named | 24 Aug 2026 |
| Same 11-man study | No difference in urinary cortisol or monoamine metabolites | PMID 2554357 | Same status | 24 Aug 2026 |
| 24 women under isoflurane anesthesia; randomized | Heart rate rose, heart-rate variability fell, delta rhythm and burst suppression fell, BIS rose at one tested level | PMID 19142086 | PubMed has no grant list; full paper not verified | 24 Aug 2026 |
| Same anesthesia study | EEG symmetry changed; authors concluded anesthesia depth was lightened | PMID 19142086 | Same status | 24 Aug 2026 |
What safety findings were reported?
The six-person study reported good tolerance and no mental, body, or lab side effects (PMID 6895513; checked 24 Aug 2026).
The 2009 anesthesia study found a faster pulse, lower HRV, and changed EEG results (PMID 19142086; checked 24 Aug 2026). Its abstract has no full harm table. The 16-person and 11-man abstracts also have none.
What does evidence tier B mean here?
Controlled human studies exist. The entry assigns tier B (checked 24 Aug 2026). The studies were small and tested different things. The tier does not set EU status.
What is the recorded EU status?
The European Commission active-substance index has no entry for Emideltide, DSIP, or delta sleep-inducing peptide (Union Register index; checked 24 Aug 2026).
The index covers central EU approvals. It does not settle national lists. The EU field remains unclear.
When was DSIP first observed in a product?
No vial test or market record is linked here (checked 24 Aug 2026). A paper or trial date is not a vial date. The first_observed field stays blank instead of using a guess.
What does this register entry cover?
This entry covers the INN, DSIP, and its sequence. It has no test result for a vial. No full guide is installed yet.